Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Ammonia and Asymmetric Dimethylarginine

Research Papers that Mention the Interaction

Ammonia also increases the concentration in the brain of the endogenous inhibitor of nitric oxide synthases (NOS), asymmetric dimethylarginine ( ADMA ), but distribution of ADMA surplus between the intraastrocytic and extracellular compartments of the brain has not been studied.
Here we tested the hypothesis that ammonia modulates the distribution of ADMA and its analog symmetric dimethylarginine (SDMA) between the two compartments of the brain by competition with arginine for the y+LAT2 transporter.
Treatment for 48 h with 5 mM ammonia led to an almost 50% reduction of ADMA and SDMA concentration in both cell types, and the effect in astrocytes was substantially attenuated by silencing of the Slc7a6 gene.
International journal of molecular sciences  •  2017  |  View Paper
High ammonia diet increased plasma ammonia and ADMA concentration, and aggravated spatial deficit in the presence of BDL‐induced cholestasis.
International Journal of Developmental Neuroscience  •  2010  |  View Paper