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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Ammonia
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“ Ammonia also increases the concentration in the brain of the endogenous inhibitor of nitric oxide synthases (NOS), asymmetric dimethylarginine ( ADMA ), but distribution of ADMA surplus between the intraastrocytic and extracellular compartments of the brain has not been studied.”
“Here we tested the hypothesis that ammonia modulates the distribution of ADMA and its analog symmetric dimethylarginine (SDMA) between the two compartments of the brain by competition with arginine for the y+LAT2 transporter.”
“Treatment for 48 h with 5 mM ammonia led to an almost 50% reduction of ADMA and SDMA concentration in both cell types, and the effect in astrocytes was substantially attenuated by silencing of the Slc7a6 gene.”
Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y+LAT2 Carrier-Mediated Loss“High ammonia diet increased plasma ammonia and ADMA concentration, and aggravated spatial deficit in the presence of BDL‐induced cholestasis.”
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