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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ammonia
supplement:
Asparagine
Research Papers that Mention the Interaction
“ Ammonia production was reduced by manipulating the amino acid composition of the culture medium; specifically, glutamine, glutamate, asparagine , aspartate, and serine levels were adjusted.”
13 C Flux Analysis Reveals that Rebalancing Medium Amino Acid Composition can Reduce Ammonia Production while Preserving Central Carbon Metabolism of CHO Cell Cultures.“The maximal rate of reaction with ammonia is 2.5 times greater than that with glutamine and 10 times greater than that with asparagine at the respective pH optima.”
“No evidence of urea cycle malfunction was found, so overproduction of ammonia through hydrolysis of plasma asparagine and glutamine seems to be the main cause.”
High incidence of symptomatic hyperammonemia in children with acute lymphoblastic leukemia receiving pegylated asparaginase.“Glutamine, glutamate, asparagine , aspartate, alanine, and serine levels decline concomitantly with ammonia accumulation.”
“ Ammonia caused large stimulatory effects in incorporation of (14)C into glutamine (a factor of 21), aspartate, asparagine , valine, alanine, arginine, and histidine.”
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