Possible Interaction: Ammonia and Arginine

“These results demonstrate that intravenous L-ARG reduces significantly exercise-induced increase in plasma lactate and ammonia.”

“ Blood ammonia concentrations tended to be higher in infants receiving the 3.6% arginine amino acid solution.”

“ Ammonia also modulates BBB transport of the cationic amino acids: the nitric oxide precursor, arginine , and ornithine, which is an ammonia trap, and affects the transport of energy metabolites glucose and creatine.”

“The enhancement of urea formation by increased endogenous levels of Orn is comparable with that produced by large doses of Orn and arginine , a treatment known to enhance the detoxification of ammonia.”

“Excitotoxic effects of ammonia are augmented by increased synthesis of nitric oxide (NO), which is associated with NMDA receptor activation and/or increased synaptic transport of arginine (ARG).”

“Adding arginine , citrulline, and ornithine to EAA for a further four days significantly lowered the mean serum ammonia level.”

“Results: l-Arginine decreased ammonia levels in a close temporal relation (case I ammonia in EDTA-plasma [μg/dL] decreased from 381 to 39; case II from 281 to 50; case III from 669 to 74; case IV from 447 to 56; case V from 202 to 60).”

“Unlike lactate, ammonia showed a curvilinear response to loss of velocity, only increasing above resting levels when R was at least two repetitions higher than 50% of P. CONCLUSIONS Velocity loss and metabolic stress clearly differs when manipulating the number of repetitions actually performed in each training set.”

“The results revealed significantly higher ammonia production from arginine in saliva (1.06 vs. 0.18; p < 0.0001) and plaque samples (1.74 vs. 0.58; p < 0.0001) from caries-free subjects compared to caries-active subjects.”

“In addition, arginine supplementation could decrease accumulations of lactate and ammonia , metabolites involved in development of muscular fatigue.”