supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Ammonia
supplement:
Alpha-Ketoglutaric Acid
Research Papers that Mention the Interaction
“ Oxoglutaric acid , an intermediate of the trycarboxilic acid cycle (TAC), has been used in order to reduce high ammonia concentrations because it can be aminated to form glutamic acid in extrahepatic tissues2,3.”
Effect of pyridoxine-2-oxoglutarate administration in patients with advanced cirrhosis: control of ammonia pyruvate and lactate high plasma concentrations.“The metabolism of α-ketoglutarate is discussed as a possible mediating mechanism for the toxicity of ammonia.”
The effect of acute hypocapnia upon the energy state of the brain in sustained hyperammonemia.“Excess α-ketoglutarate (greater than 0.5 m m ) inhibits the production of ammonia from alanine and aspartate.”
“Addition of ammonia inhibits oxygen uptake in phosphorylating rat-liver mitochondria when α-ketoglutarate or pyruvate is used as substrate.”
“The level of pyruvate, α-ketoglutarate and malate accumulated is lower if ammonia was added to the medium, which indicates the onset of amino acid synthesis.”
[Control of aerobic metabolism in starved yeast cells supplied with glucose and ammonia].“In the course of an investigation of this problem it was found that ammonia strongly inhibits the exogenous utilization of glucose, pyruvate, citrate, α-ketoglutarate , succinate and malate by a number of intact tissues and particulate preparations from plant sources.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback