Possible Interaction: Amlodipine and Calcium Supplement

“The new 1,4-dihydropyridine calcium antagonist amlodipine has been shown to inhibit calcium accumulation in the internal elastic membrane of abdominal arteries of NaCl-loaded salt-sensitive Dahl-S rats, and consequently also exerts protective effects against arteriosclerotic lesions, shown particularly in the distal mesenteric artery branches.”

“ Amlodipine is a dihydropyridine-derived selective calciumchannel blocker that inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle.”

“ Amlodipine is a member of the dihydropyridine class of calcium antagonists which selectively inhibit the influx of calcium ions across the cell membranes.”

“In addition, amlodipine reduced serum concentrations of calcium , PTH and CTx.”

“ Amlodipine treatment at doses of 1 and 3 mg/kg significantly increased the calcium (P<0.01) and phosphor concentrations (P<0.01) in the femurs of ovariectomized rats, compared to those of control (ovariectomized) group.”

“On the other hand amlodipine treatment at doses of 1 and 3 mg/kg significantly increased the calcium (P<0.01) and phosphor concentrations (P<0.01) in the femurs of ovariectomized rats compared with those of the sham group.”

“Moreover, amlodipine partially reversed the effect of dietary Ca on alpha-vascular reactivity.”

“Inhibition of intracellular calcium increases wasachieved using nM concentrations of felodipine or amlodipine.”

“Moreover, the lack of antagonistic effect between amlodipine and Bay K 8644 suggests that, in addition to its L-type Ca2+ channel inhibitory effect, amlodipine inhibits other intracellular signaling pathways.”

“The blocking action of amlodipine on the N‐type Ca2+ channel was dependent on holding potential and extracellular pH, as has been observed with amlodipine block on the L‐type Ca2+ channel.”

“ Amlodipine treatment caused a rapid concentration-dependent decrease of intracellular calcium concentration in the HT-39 cell line.”