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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Amitriptyline and Yohimbine



Research Papers that Mention the Interaction

Yohimbine potentiated the effect of nortriptyline or amitriptyline administered in a single dose and the effect of imipramine and amitriptyline given for 2 weeks.
Psychopharmacology  •  2004  |  View Paper
Two but not one week of treatment with amitriptyline (AMI) produces subsensitivity to the hypothermic effects of the alpha 2 antagonist yohimbine.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  1989  |  View Paper
Amitriptyline (10 mg/kg, twice daily) in combination with yohimbine (5 mg/kg, twice daily) decreased 5HT2 receptor binding after 4 days of treatment, whereas amitriptyline alone required 10 days to decrease the density of 5HT2 receptors.
Neuropharmacology  •  1983  |  View Paper
Yohimbine and phentolamine administered in doses regarded as blocking presynaptic alpha-adrenoreceptors counteracted locomotor sedation elicited in rats by antidepressant drugs (imipramine, nortriptyline and amitriptyline).
Polish journal of pharmacology and pharmacy  •  1980  |  View Paper