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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amitriptyline
supplement:
Yohimbine
Research Papers that Mention the Interaction
“ Yohimbine potentiated the effect of nortriptyline or amitriptyline administered in a single dose and the effect of imipramine and amitriptyline given for 2 weeks.”
Presynaptic α-adrenoceptors and the action of tricyclic antidepressant drugs in behavioural despair in rats“Two but not one week of treatment with amitriptyline (AMI) produces subsensitivity to the hypothermic effects of the alpha 2 antagonist yohimbine.”
Chronic treatment with amttriptyline produces subsensitivity to the hypothermic effects of yohimbine“ Amitriptyline (10 mg/kg, twice daily) in combination with yohimbine (5 mg/kg, twice daily) decreased 5HT2 receptor binding after 4 days of treatment, whereas amitriptyline alone required 10 days to decrease the density of 5HT2 receptors.”
“ Yohimbine and phentolamine administered in doses regarded as blocking presynaptic alpha-adrenoreceptors counteracted locomotor sedation elicited in rats by antidepressant drugs (imipramine, nortriptyline and amitriptyline).”
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