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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amitriptyline
supplement:
Tryptophan
Research Papers that Mention the Interaction
“Both desipramine (N = 7) and amitriptyline (N = 6) significantly increased the PRL rise induced by tryptophan compared with a preceding placebo period.”
Serotonin function and mechanism of action of antidepressant treatment. Effects of amitriptyline and desipramine.“There was a significantly positive correlation between the pretreatment plasma tryptophan ratio and the final depression score in patients treated with L-tryptophan or amitriptyline , and a trend towards a positive correlation in patients treated with lithium plus L-tryptophan or clomipramine.”
“SummaryIn rats, chronic amitriptyline (14 days, 10 mg/kg, IP) administration resulted in a significant increase in the serum glutamate concentration and concomitant increase in the serum free tryptophan.”
Effects of amitriptyline on serum glutamate and free tryptophan in rats“This study was performed to investigate if the antidepressant agents amitriptyline and clomipramine could, by such a mechanism, increase brain concentrations of administered tryptophan.”
“ Amitriptyline caused decreased concentrations in rat plasma … the amino acids tyrosine and tryptophan , which are precursors to monoaminergic neurotransmitters, and also of those other large neutral amino acids (LNAAs) (valine, phenylalanine, … and isoleucine) with which tyrosine and tryptophan compete for the carrier‐mediated transport from plasma into the brain.”
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