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Last Updated: 2 years ago

Possible Interaction: Amitriptyline and St John's Wort

Research Papers that Mention the Interaction

Lastly, multiple herb-drug interactions have been identified with St. John's wort that involve significantly reduced AUC and blood concentrations of warfarin, digoxin, indinavir, theophylline, cyclosporine, tacrolimus, amitriptyline , midazolam, and phenprocoumon.
Current medicinal chemistry  •  2011  |  View Paper
Results from clinical studies and case reports indicate that self-administered SJW reduce steady state plasma concentrations of amitriptyline , cyclosporine, digoxin, fexofenadine, amprenavir, indonavir, lopinavir, ritonavir, saquinavir, benzodiazepines, theophyline, irinotecan, midazolan and warfarin.
Life sciences  •  2006  |  View Paper
St John's wort also enhances the metabolism of other CYP3A4 substrates including the protease inhibitors indinavir and nevirapine, oral contraceptives, and tricyclic antidepressants such as amitriptyline.
Xenobiotica; the fate of foreign compounds in biological systems  •  2002  |  View Paper
For example, St John's wort significantly reduced the area under the plasma concentration-time curve (AUC) and blood concentrations of cyclosporine, midazolam, tacrolimus, amitriptyline , digoxin, indinavir, warfarin, phenprocoumon and theophylline.
Current drug metabolism  •  2012  |  View Paper
Clinical trials indicate …’s wort Hypericum perforatum ), via cytochrome P450 (CYP) and/or P-glycoprotein induction, … concentrations (and/or increases the clearance) of alprazolam, amitriptyline , atorvastatin, chlorzoxazone, ciclosporin, debrisoquine, digoxin, erythromycin, fexofenadine, gliclazide, imatinib, indinavir, irinotecan, ivabradine, …, nifedipine, omeprazole, oral contraceptives, quazepam, simvastatin, tacrolimus, talinolol, verapamil, voriconazole and warfarin.
Drugs  •  2012  |  View Paper
Recently, a variety of case reports … interactions due to drug combinations with St. John's wort have been published (e.g. cellular rejection of pancreas-, kidney- as well as heart transplants with … of INR with oral anticoagulants, bleeding with oral contraceptives, reduction of plasma concentration of digoxin, indinavir, amitriptyline, …).
Praxis  •  2001  |  View Paper
The results … that St John's wort (Hypericum perforatum) lowers blood concentrations of cyclosporin, amitriptyline , digoxin, indinavir, warfarin, phenprocoumon and theophylline; furthermore it causes intermenstrual bleeding, delirium or mild serotonin syndrome, respectively, when used concomitantly with oral contraceptives (ethinylestradiol/desogestrel), loperamide or selective serotonin-reuptake inhibitors (sertaline, paroxetine, nefazodone).
Drugs  •  2001  |  View Paper
Perhaps the … is St. John's Wort (Hypericum perforatum), which reduces the … of many drugs such as amitriptyline , digoxin, theophylline, non-steroidal anti-inflammatories (NSAIDs), and oral contraceptive pills.13 St. John's Wort … increases the activity and expression of multidrug transporter P-glycoprotein efflux pumps in the duodenum.
The Australasian medical journal  •  2015  |  View Paper