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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Amitriptyline and Sodium Bicarbonate

Research Papers that Mention the Interaction

Conclusion Empirical treatment with sodium bicarbonate or hypertonic saline can reduce the development of cardiotoxicity during amitriptyline intoxication.
Cardiovascular journal of Africa  •  2015  |  View Paper
Alkalinization with NaHCO3 can effectively reverse ventricular arrhythmias caused by amitriptyline intoxication, but the mechanism is unclear.
However, the magnitude of improvement of phase 0 characteristics was significantly greater after high NaHCO3 and resulted in significant improvement of conduction velocity in fibers depressed by amitriptyline.
The Journal of pharmacology and experimental therapeutics  •  1984  |  View Paper
Physostigmine, propranolol, sodium bicarbonate , and left stellate ganglionectomy reversed the effect of amitriptyline on RET.
Clinical pharmacology and therapeutics  •  1980  |  View Paper