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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amitriptyline
supplement:
Quinidine
Research Papers that Mention the Interaction
“Plasma concentrations of AMI were not influenced by novobiocin, probenecid and the lack of Abcb1, but were significantly increased by quinidine , resulting from the inhibition of hydroxylation mediated by CYP2D6.”
Influence of efflux transporters on liver, bile and brain disposition of amitriptyline in mice.“Absolute oral bioavailability (F) of amitriptyline was significantly increased more than three-fold in presence of quinidine (F = 0.6+/-0.4% versus 1.9+/-1.1%).”
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