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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amitriptyline
supplement:
Phenethylamines
Research Papers that Mention the Interaction
“Also at the higher levels of oxygen, amitriptyline inhibition of PEA deamination approached a competitive fashion.”
EVIDENCE FOR A SINGLE CATALYTIC BINDING SITE ON HUMAN BRAIN TYPE B MONOAMINE OXIDASE“The I50 for the inhibition by amitriptyline was 4 × 10 −6 M, 1.6 × 10 −5 M, and 2 × 10 −4 M when phenylethylamine , tryptamine, and benzylamine were used as substrates.”
“ Amitriptyline , at a concentration of 10(-5) M, inhibits the oxidative deamination of phenylethylamine , tyramine and tryptamine (by 40, 16, and 8 percent, respectively) by rat brain MAO.”
Does long term treatment with amitriptyline alter the monoamine oxidase of rat brain?
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