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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Amitriptyline and Glycine



Research Papers that Mention the Interaction

Amitriptyline (30 μM) significantly increased mIPSC frequency without affecting the current amplitude, suggesting that amitriptyline acts presynaptically to increase the probability of glycine release.
Amitriptyline also directly inhibited the glycine receptor-mediated Cl(-) currents induced by lower concentrations of glycine.
These data suggest that amitriptyline increases spontaneous glycine release onto acutely isolated medullary dorsal neurons by increasing the intraterminal Ca(2+) concentration, which might be mediated by the Ca(2+) release from the Ca(2+) stores rather than the Ca(2+) influx from the extracellular space.
Brain Research  •  2012  |  View Paper
Results showed that when combined with GLY , ADS whose main pharmacological effect is one of 5-HT uptake blockade (imipramine, amitriptyline , citalopram, paroxetine, fluoxetine, and fluvoxamine) were more effective in decreasing the amount of time mice were immobile, than when these drugs were administered alone.
Pharmacology Biochemistry and Behavior  •  1996  |  View Paper