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Last Updated: 2 years ago

Possible Interaction: Amitriptyline and Epinephrine

supplement:

Epinephrine

Research Papers that Mention the Interaction

I present this case study as another example of drugs with alpha adrenergic receptor blocking activity (thioridazine and amitriptyline ) obstructing the action of adrenaline in anaphylactic collapse.
Australian family physician  •  1998  |  View Paper
Chlorpromazine, amitriptyline and idazoxin inhibited larval metamorphosis induced by 10−4 M epinephrine.
Biofouling  •  2011  |  View Paper
Combined injection of amitriptyline with epinephrine in the threshold doses (ineffective if used alone), 1/10 and 1/30 minimum effective doses, respectively, leads to the development of the maximum analgesic and antidepressant effect, but causes no sedative side effect.
Bulletin of Experimental Biology and Medicine  •  2007  |  View Paper
Coinjection of amitriptyline and bupivacaine with epinephrine enhances the analgesic duration of both drugs.
Anesthesiology  •  2002  |  View Paper
The results revealed that chronic treatment with amitriptyline resulted in significantly increased rises in delta [Ca2+]i after stimulation with 20 microM of carbachol or adrenaline , and a significant increase in muscarinic acetylcholine receptor density.
European journal of pharmacology  •  1992  |  View Paper