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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amitriptyline
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Treatment with amitriptyline reduced levels of corticotropin and corticosterone, increased glucocorticoid receptor mRNA concentrations and glucocorticoid binding capacity of several brain areas, and reversed behavioural changes.”
Regulation of corticosteroid receptor gene expression in depression and antidepressant action.“A U-shaped concentration-dependent response curve was observed in ACTH level in response to amitriptyline exposure.”
Growth inhibition and coordinated physiological regulation of zebrafish (Danio rerio) embryos upon sublethal exposure to antidepressant amitriptyline.“ ACTH co-administered with AMI or NOM in a single dose or with AMI, IMI or NOM for 7 days potentiated the antiimmobility effect of antidepressant drugs.”
“It was concluded that the specific synergism exists only between ACTH and tricyclic antidepressants ( AMI , IMI).”
“Concerning the neuroendocrine implications of chronic antidepressant treatment, amitriptyline (5 weeks, 4.5 mg/kg.day) produced significant decreases in basal ( ACTH , -47%; corticosterone, -31%) as well as stress (30 min novel environment)-induced plasma ACTH (-38%) and corticosterone (-57%) levels.”
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