Possible Interaction: Amiodarone and Vitamin E

“ Amiodarone effectiveness was lowered by lipoprotein alpha-tocopherol enrichment, suggesting some drug-alpha-tocopherol interaction and less lipid pharmacological protection at higher alpha-tocopheroxyl radical generation.”

“2 It has recently been shown that α‐tocopherol (α‐Toc) inhibits drug‐ and PL accumulation in cell cultures chronically exposed to the CAD, amiodarone.”

“Results from the present study showed that alpha-TOC reduced phospholipidosis in cultured human skin fibroblasts chronically exposed to micromolar concentrations of AMIO and DEA and inhibited cumulative uptake of the drugs in a dose-dependent manner.”

“The finding raises hope that side-effects of AMIO and DEA can be prevented or made reversible by the administration of alpha-TOC.”

“In addition, all the antioxidants tested reduced the superoxide anion detected, but only alpha-tocopherol prevented lipid peroxidation induced by amiodarone.”

“The hydrophilic antioxidants had no effect on the toxicity of amiodarone , whereas alpha-tocopherol at a concentration >100 micromol/L almost completely suppressed it.”

“Amiodarone treatment significantly increased, and both silymarin and vitamin E combined with amiodarone significantly decreased, the conjugated diene content of liver homogenate compared with amiodarone treatment alone.”

“Dietary vitamin E supplementation for 6 weeks resulted in a 234% increase in lung vitamin E content at the time of AM dosing, and maintenance on the diet prevented AM-induced elevation of hydroxyproline content and disease index 21 days post-dosing.”

“Additionally, the toxic effect of amiodarone on the cells was depressed by pretreatment of them with docosahexaenoic acid (DHA) or alpha-tocopherol for 2 days and co-treatment with these agents for 1 day, but not with prednisolone or indomethacin co-treatment.”

“ΔW = 0.05 ± 0.02 … for 3 days with vitamin E (Vit E, 300 U/day orally, ΔW = 0.6 ± 0.2 g/min, p < 0.05), or addition of … mM, ΔW = 0.1 ± 0.08 g/min, p < 0.01) all protect from lung edema formation after amiodarone.”

“Conclusions Oral administration of amiodarone in rats resulted in ultrastructural changes in atria, which can be attenuated by vitamin E co-administration.”

“Concomitant administration of vitamin E with amiodarone showed a considerable preservation of the atrial architecture.”

“Conclusion: Milder hepatotoxic effects are seen in rats administered amiodarone and vitamin E simultaneously suggesting that vitamin-E may play a role in amelioration of the effects of amiodarone.”