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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amiodarone
supplement:
Silymarin
Research Papers that Mention the Interaction
“We tested whether simultaneous administration of a flavonoid antioxidant, silymarin , altered the electrophysiologic (EP) actions of amiodarone in 62 open chest dogs with electrically induced atrial flutter created by a Y‐shaped right atrial incision.”
Combined Amiodarone and Silymarin Treatment, But Not Amiodarone Alone, Prevents Sustained Atrial Flutter in Dogs“ Silymarin significantly (P=0.021) reduced liver amiodarone , but only tended to decrease desethylamiodarone concentration; however, vitamin E failed to do so.”
“Amiodarone treatment significantly increased, and both silymarin and vitamin E combined with amiodarone significantly decreased, the conjugated diene content of liver homogenate compared with amiodarone treatment alone.”
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