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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amiodarone
supplement:
Potassium
Research Papers that Mention the Interaction
“The break in amiodarone and a medical treatment (synthetic antithyroid drugs, steroids, perchlorate of potassium ) can be ineffective.”
[Value of total thyroidectomy in amiodarone-induced hyperthyroidism].“Antiarrhythmic drugs class IA (…), class III (sotalol, amiodarone ), class IV (calcium channel blockers) … at the same time with potassium depleters diuretics or beta-blocking agents result in the inhibition of repolarization and the increased duration … activation potential with the risk of developing arrhythmia of the torsade de pointes types.”
“ Amiodarone effectively blocks both the sodium and calcium channels and beta-adrenoceptors, in addition to blocking several potassium currents including IKr, IKs, Ito, IK1, IKACh and IKNa.”
Comparison of the in vivo electrophysiological and proarrhythmic effects of amiodarone with those of a selective class III drug, sematilide, using a canine chronic atrioventricular block model.“In addition to its β‐blocking properties, amiodarone is known lo block the sodium, potassium , and calcium channels in the heart.”
“ Amiodarone inhibits the magnesium-dependent enzyme of all preparations in the same way as it acts on guinea pig heart sodium and potassium activated magnesium-dependent ATPase; 6 inhibition was shown, in the case of heart “actomyosin”, to be competitive with respect to ATP, not to magnesium.”
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