“In 13 cells, peak ICa L was blocked by 85% after amiodarone application.”
“In other cells, amiodarone was applied for 30 sec without any stimulation; and, when stimulation was resumed, the ICa,L amplitude … the first pulse was 22% of the control amplitude (n = 4), indicating that a substantial portion of the blockade of ICa L by amiodarone was tonic in nature.”