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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amiodarone
supplement:
Epinephrine
Research Papers that Mention the Interaction
“ Epinephrine infusion, at both 25 and 50 ng/kg per min, completely reversed the effects of quinidine and partially reversed the effects of amiodarone on the effective refractory period.”
Reversal of antiarrhythmic drug effects by epinephrine: quinidine versus amiodarone.“The number of electric shocks required for terminating VF, time to ROSC and adrenaline dose were significantly higher with amiodarone compared to nifekalant (p < 0.001).ConclusionsNifekalant showed a more favorable hemodynamic profile and improved survival compared to amiodarone and saline in this swine model.”
Nifekalant Versus Amiodarone in the Treatment of Cardiac Arrest: an Experimental Study in a Swine Model of Prolonged Ventricular Fibrillation“ Amiodarone administered alone produces significantly lower coronary perfusion pressure than when combined with adrenaline.”
“ Amiodarone combined with adrenaline produced pressures during CPR similar to adrenaline alone.”
“Flecainide, E-4031, and verapamil markedly reduced the duration of arrhythmias induced by epinephrine, 8 µg/kg intravenously (P < 0.01), whereas only amiodarone markedly reduced the duration of arrhythmias Induced by epinephrine , 16 µg/kg intravenously (P < 0.01).”
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