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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Amiodarone and Choline

supplement:

Choline

Research Papers that Mention the Interaction

Amiodarone produced a marked and significant (p less than 0.05) dose dependent reduction in choline uptake.
Cardiovascular research  •  1992  |  View Paper
Amiodarone and desethylamiodarone at 10(-6) to 10(-4) M produced a significant (P less than 0.05) dose dependent reduction in choline uptake and inhibited the specific or carrier-mediated uptake process.
Amiodarone but not desethylamiodarone produced a small but significant (P less than 0.05) increase in the amount of label that accumulated in CDP choline.
These data demonstrate that amiodarone and desethylamiodarone decrease choline uptake into cardiac cells that may potentially be involved in either the mechanism of action or toxicity of amiodarone.
Journal of molecular and cellular cardiology  •  1990  |  View Paper