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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Amiodarone and Arachidonic Acid

Research Papers that Mention the Interaction

Amiodarone enhanced the maximal level of agonist-stimulated release of arachidonic acid (AA) from Chinese hamster ovary cells that expressed M3 muscarinic receptors; this enhancement was observed for acetylcholine and for the partial agonist pilocarpine.
Molecular Pharmacology  •  2011  |  View Paper
Dronedarone, amiodarone and NDBD inhibit rhCYP2J2‐mediated metabolism of AA to 14,15‐EET with Ki values of 3.25, 5.48, 1.39 &mgr;M respectively.
Biochemical pharmacology  •  2017  |  View Paper
The release of 45Ca2+ from the endoplasmic reticulum stores by the putative intracellular second messengers inositol-1,4,5-trisphosphate, arachidonic acid , and Ca2+ was blocked by amiodarone treatment.
Toxicology and applied pharmacology  •  1990  |  View Paper