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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amiodarone
supplement:
Arachidonic Acid
Research Papers that Mention the Interaction
“ Amiodarone enhanced the maximal level of agonist-stimulated release of arachidonic acid (AA) from Chinese hamster ovary cells that expressed M3 muscarinic receptors; this enhancement was observed for acetylcholine and for the partial agonist pilocarpine.”
Allosteric Modulation of the M3 Muscarinic Receptor by Amiodarone and N-Ethylamiodarone: Application of the Four-Ligand Allosteric Two-State Model“Dronedarone, amiodarone and NDBD inhibit rhCYP2J2‐mediated metabolism of AA to 14,15‐EET with Ki values of 3.25, 5.48, 1.39 &mgr;M respectively.”
“The release of 45Ca2+ from the endoplasmic reticulum stores by the putative intracellular second messengers inositol-1,4,5-trisphosphate, arachidonic acid , and Ca2+ was blocked by amiodarone treatment.”
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