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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Aminopyrine
supplement:
Vitamin C
Research Papers that Mention the Interaction
“The distinct inhibitory action of ascorbic acid was verified under simulated conditions of the human stomach in further 9 drugs undergoing nitrosation at different rates, which contain the active agents: aminophenazone , clomipramine, imipramine, desipramine, ampicilline, oxacilline, phenoxymethylpenicilline, ethambutole or piperazine.”
[Effect of nontoxic inhibitors on the nitrosation of drugs under conditions simulating the human stomach].“ Vitamin C synthesis in rat liver is enhanced by several xenobiotics, including aminopyrine and chloretone.”
Rapid Stimulation of Free Glucuronate Formation by Non-glucuronidable Xenobiotics in Isolated Rat Hepatocytes*“Additional in vivo studies demonstrate that simultaneous oral administration of ascorbic acid prevents the mutagenicity that follows the intragastric nitrosation of aminopyrine by nitrite while dietary pre-treatment with ascorbic acid does not.”
“The administration of xenobiotics, PCB, DDT, or aminopyrine to rats causes a marked increase in urinary excretion of ascorbic acid and in various tissue levels of ascorbic acid.”
“Other types of compounds, such as chloretone, aminopyrine , meprobamate and phenylbutazone, also increase the urinary excretion of ascorbic acid in rats2,3.”
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