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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aminopyrine
supplement:
Niacin
Research Papers that Mention the Interaction
“ Nicotinamide injection was also shown to bring about a significant increase in the levels of host hepatic cytochromes P-450 and b5 and in the activities of aminopyrine demethylase and UDP-glucuronosyl transferase which were shown to be low in the tumour-bearing rats.”
Effect of nicotinamide on hepatic microsomal drug metabolising system in tumour-bearing rats and mice.“Nicotinic acid and nicotinamide injected to rats subcutaneously in a dose of 100 mg/kg produce after 4 hours an inhibition in liver microsomes of N-demethylation of amidopyrine , NADPH.H-ferricytochromo-c-, NAD.H-ferricytochromo-b5-oxidoreductases and NAD.H-oxidase.”
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