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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aminopyrine
supplement:
Gossypol
Research Papers that Mention the Interaction
“In vitro, gossypol inhibited aminopyrine N-demethylase activity, the concentration causing 50% inhibition being approximately 0.03 mM; the inhibition was non-competitive.”
“In vivo, gossypol , after 4 weeks of daily administration (30 mg/kg/day) caused a significant reduction in microsomal protein, cytochrome P450 and aminopyrine N-demethylase activity.”
Inhibition of hepatic microsomal enzymes by gossypol in the rat.
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