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Discover Supplement-Drug Interactions

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Last Updated: a month ago

Possible Interaction: Aminopyrine and Gossypol

supplement:

Gossypol

Research Papers that Mention the Interaction

In vitro, gossypol inhibited aminopyrine N-demethylase activity, the concentration causing 50% inhibition being approximately 0.03 mM; the inhibition was non-competitive.
In vivo, gossypol , after 4 weeks of daily administration (30 mg/kg/day) caused a significant reduction in microsomal protein, cytochrome P450 and aminopyrine N-demethylase activity.
Contraception  •  1984  |  View Paper