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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Aminopyrine
supplement:
Glutathione
Research Papers that Mention the Interaction
“ Glutathione reduces the aminopyrine cation free radical, the formation of which is catalyzed by the hydroperoxidase, back to the parent compound.”
The mechanism for the inhibition of prostaglandin H synthase-catalyzed xenobiotic oxidation by methimazole. Reaction with free radical oxidation products.“The addition of phenol or aminopyrine to incubations, which greatly enhances the oxidation of glutathione to a thiyl radical by peroxidases, increased the formation of styrene glutathione adducts.”
“The infusion of 0.8 mM aminopyrine led to a rapid rise in the amount of GSH released into the bile with only a small increase in the amount of GSSG released; caval GSH + GSSG efflux was unaffected.”
“The pyrazolone derivatives aminophenazone , phenazone, and propyphenazone are capable of decreasing reduced glutathione (GSH) in the liver after a single dose of 3 mmol/kg.”
“Reduced glutathione level in the liver was not changed after 5 days of treatment but a significant increase was seen after 15 days of aminopyrine treatment.”
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