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The Journal of biological chemistry • 1987 | View Paper
“The addition of phenol or aminopyrine to incubations, which greatly enhances the oxidation of glutathione to a thiyl radical by peroxidases, increased the formation of styrene glutathione adducts.”
The Journal of biological chemistry • 1986 | View Paper
“The infusion of 0.8 mM aminopyrine led to a rapid rise in the amount of GSH released into the bile with only a small increase in the amount of GSSG released; caval GSH + GSSG efflux was unaffected.”
“The pyrazolone derivatives aminophenazone , phenazone, and propyphenazone are capable of decreasing reduced glutathione (GSH) in the liver after a single dose of 3 mmol/kg.”
“Reduced glutathione level in the liver was not changed after 5 days of treatment but a significant increase was seen after 15 days of aminopyrine treatment.”