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Last Updated: 2 months ago

Possible Interaction: Aminopyrine and Glutathione

supplement:

Glutathione

Research Papers that Mention the Interaction

Reduced glutathione in high concentrations, as in the red cell, substantially diminished binding of oxidized DMAP to hemoglobin by formation of S,S,S-(2-dimethylamino-5-hydroxy-1,3,4-phenylene)-tris-glutathione (tris-(GS)-DMAP), which does not form ferrihemoglobin.
Chemico-biological interactions  •  1976  |  View Paper
Since DMAP upon oxidation forms bis- and tris-substituted thioethers with GSH , it was anticipated that mitochondrial toxicity of DMAP might result from CoA depletion.
Biochemical pharmacology  •  1989  |  View Paper
Glutathione reduces the aminopyrine cation free radical, the formation of which is catalyzed by the hydroperoxidase, back to the parent compound.
The Journal of biological chemistry  •  1987  |  View Paper
The addition of phenol or aminopyrine to incubations, which greatly enhances the oxidation of glutathione to a thiyl radical by peroxidases, increased the formation of styrene glutathione adducts.
The Journal of biological chemistry  •  1986  |  View Paper
The infusion of 0.8 mM aminopyrine led to a rapid rise in the amount of GSH released into the bile with only a small increase in the amount of GSSG released; caval GSH + GSSG efflux was unaffected.
Biochemical pharmacology  •  1985  |  View Paper
The pyrazolone derivatives aminophenazone , phenazone, and propyphenazone are capable of decreasing reduced glutathione (GSH) in the liver after a single dose of 3 mmol/kg.
Biomedica biochimica acta  •  1983  |  View Paper
Reduced glutathione level in the liver was not changed after 5 days of treatment but a significant increase was seen after 15 days of aminopyrine treatment.
Life sciences  •  1982  |  View Paper