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Last Updated: 4 months ago

Possible Interaction: Aminopyrine and Glutathione



Research Papers that Mention the Interaction

Reduced glutathione in high concentrations, as in the red cell, substantially diminished binding of oxidized DMAP to hemoglobin by formation of S,S,S-(2-dimethylamino-5-hydroxy-1,3,4-phenylene)-tris-glutathione (tris-(GS)-DMAP), which does not form ferrihemoglobin.
Chemico-biological interactions  •  1976  |  View Paper
Since DMAP upon oxidation forms bis- and tris-substituted thioethers with GSH , it was anticipated that mitochondrial toxicity of DMAP might result from CoA depletion.
Biochemical pharmacology  •  1989  |  View Paper
Glutathione reduces the aminopyrine cation free radical, the formation of which is catalyzed by the hydroperoxidase, back to the parent compound.
The Journal of biological chemistry  •  1987  |  View Paper
The addition of phenol or aminopyrine to incubations, which greatly enhances the oxidation of glutathione to a thiyl radical by peroxidases, increased the formation of styrene glutathione adducts.
The Journal of biological chemistry  •  1986  |  View Paper
The infusion of 0.8 mM aminopyrine led to a rapid rise in the amount of GSH released into the bile with only a small increase in the amount of GSSG released; caval GSH + GSSG efflux was unaffected.
Biochemical pharmacology  •  1985  |  View Paper
The pyrazolone derivatives aminophenazone , phenazone, and propyphenazone are capable of decreasing reduced glutathione (GSH) in the liver after a single dose of 3 mmol/kg.
Biomedica biochimica acta  •  1983  |  View Paper
Reduced glutathione level in the liver was not changed after 5 days of treatment but a significant increase was seen after 15 days of aminopyrine treatment.
Life sciences  •  1982  |  View Paper