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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aminopterin
supplement:
Vitamin C
Research Papers that Mention the Interaction
“Rats fed aminopterin exhibit a concentration of liver ascorbic acid less than one-half normal, indicating that folic acid is probably involved in ascorbic acid synthesis in the rat.”
Interrelationships of Folic Acid and Ascorbic Acid in Rat Liver.∗“ Aminopterin decreased urinary excretion of ascorbic acid but did not decrease excretion in chloretone-fed rats.”
Metabolism Interrelationship between Ascorbic Acid and pteroylglutamic Acid“It has also been shown by Williams (7) that the ascorbic acid content of the rat liver is decreased markedly by dietary aminopterin.”
“Recently, Williams (5, 6) has reported that the lowered choline oxidase activity of the livers of rats fed aminopterin is stimulated in vitro by the addition of ascorbic acid.”
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