Possible Interaction: Aminopterin and Thiamine

“79:827, 1960) presented evidence that aminopterin enters the cells of Bacillus subtilis mainly … active transport by the thiamine permease, and that the addition of small amounts of thiamine or a similar pyrimidine affords a great deal of protection against the growth inhibition caused by aminopterin (Pine, J. Bacteriol.”

“2) In washed-cell suspensions thiamin interferes with the uptake of aminopterin , but not of folic acid.”