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“The binding of folic acid to the human binder was inhibited by folate > H4-folate > methyl-H4-folate ≃dihydrofolate ≃ pteroic acid ≫ methotrexate ≃ aminopterin.”
The Journal of pharmacology and experimental therapeutics • 1962 | View Paper
“SummaryA rapid microbial (S. faecalis) pad-plate assay procedure, specific for thymine and thymidine, is described, in which response to folic acid and its derivatives is prevented by aminopterin.”
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine • 1954 | View Paper
“On concomitant administration of citrovorum factor or prior administration of folic acid , with a specified dose of aminopterin , both the mortality response and the increase in survival time ordinarily resulting from treatment with that dose of aminopterin were reduced.”
“ Aminopterin is a potent antimetabolite as evidenced by inhibition ratios, determined with Streptococcus faecalis R, of less than 1 at certain concentrations of folic acid.”
“While the bacteriostatic activity of low levels of aminopterin may be reversed with folic acid , high levels are not reversed in bacteria, mice, and rats and chicks.”