Possible Interaction: Aminopterin and Folic Acid

“The binding of folic acid to the human binder was inhibited by folate > H4-folate > methyl-H4-folate ≃dihydrofolate ≃ pteroic acid ≫ methotrexate ≃ aminopterin.”

“ Aminopterin competes with folic acid to prevent its conversion to folinic acid and also competes with folinic acid in its biochemical reactions.”

“The inhibition produced by A-ninopterin is strictly competitive, being released over wide ranges of concentration of folic acid.”

“ Folic acid and aminopterin counteracted the effect even better.”

“Such compounds have included a variety of sulphonamides1,2 and aminopterin3 which act as inhibitors of folic acid mediated C6-methylation.”

“Mice were given a lethal dose of aminopterin 1 hour after a protective injection of folic acid.”

“SummaryA rapid microbial (S. faecalis) pad-plate assay procedure, specific for thymine and thymidine, is described, in which response to folic acid and its derivatives is prevented by aminopterin.”

“On concomitant administration of citrovorum factor or prior administration of folic acid , with a specified dose of aminopterin , both the mortality response and the increase in survival time ordinarily resulting from treatment with that dose of aminopterin were reduced.”

“These data suggest that there is a metabolic displacement of folic acid by Aminopterin.”

“ These data suggest that there is a metabolic displacement of folic acid by Aminopterin.”

“ Aminopterin is a potent antimetabolite as evidenced by inhibition ratios, determined with Streptococcus faecalis R, of less than 1 at certain concentrations of folic acid.”

“While the bacteriostatic activity of low levels of aminopterin may be reversed with folic acid , high levels are not reversed in bacteria, mice, and rats and chicks.”