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Last Updated: 2 months ago

Possible Interaction: Aminopterin and Folic Acid

supplement:

Folic Acid

Research Papers that Mention the Interaction

The binding of folic acid to the human binder was inhibited by folate > H4-folate > methyl-H4-folate ≃dihydrofolate ≃ pteroic acid ≫ methotrexate ≃ aminopterin.
Neurochemical Research  •  2004  |  View Paper
Aminopterin competes with folic acid to prevent its conversion to folinic acid and also competes with folinic acid in its biochemical reactions.
Archives of dermatology  •  1961  |  View Paper
The inhibition produced by A-ninopterin is strictly competitive, being released over wide ranges of concentration of folic acid.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1951  |  View Paper
Folic acid and aminopterin counteracted the effect even better.
Folia Microbiologica  •  2008  |  View Paper
Such compounds have included a variety of sulphonamides1,2 and aminopterin3 which act as inhibitors of folic acid mediated C6-methylation.
Nature  •  1964  |  View Paper
Mice were given a lethal dose of aminopterin 1 hour after a protective injection of folic acid.
The Journal of pharmacology and experimental therapeutics  •  1962  |  View Paper
SummaryA rapid microbial (S. faecalis) pad-plate assay procedure, specific for thymine and thymidine, is described, in which response to folic acid and its derivatives is prevented by aminopterin.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1954  |  View Paper
On concomitant administration of citrovorum factor or prior administration of folic acid , with a specified dose of aminopterin , both the mortality response and the increase in survival time ordinarily resulting from treatment with that dose of aminopterin were reduced.
Cancer research  •  1953  |  View Paper
These data suggest that there is a metabolic displacement of folic acid by Aminopterin.
These data suggest that there is a metabolic displacement of folic acid by Aminopterin.
Blood  •  1952  |  View Paper
Aminopterin is a potent antimetabolite as evidenced by inhibition ratios, determined with Streptococcus faecalis R, of less than 1 at certain concentrations of folic acid.
While the bacteriostatic activity of low levels of aminopterin may be reversed with folic acid , high levels are not reversed in bacteria, mice, and rats and chicks.
Vitamins and hormones  •  1951  |  View Paper
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