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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aminophylline
supplement:
Melatonin
Research Papers that Mention the Interaction
“Pretreatment with the NO mimetic, L-arginine (500 and 1000 mg/kg) and melatonin (50 mg/kg) attenuated aminophylline induced anxiogenesis whereas the NO synthase inhibitors, L-NAME and 7-NI (30 mg/kg) aggravated the anxiogeneic response.”
Differential neuromodulatory role of NO in anxiety and seizures: an experimental study.“Pretreatments with antioxidants, ascorbic acid, alpha-tocopherol and melatonin , all dose dependently reduced seizure incidence and mortality after aminophylline , whereas, antioxidant depletion potentiated such excitotoxicity.”
“The protective action of melatonin (50 mg/kg) in the electroconvulsive threshold test was reversed by aminophylline , picrotoxin and bicuculline.”
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