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Last Updated: 2 years ago

Possible Interaction: Aminophylline and Epinephrine

supplement:

Epinephrine

Research Papers that Mention the Interaction

Infusion of aminophylline had only a minor inhibitory effect on the action of epinephrine.
Acta medica Scandinavica  •  1971  |  View Paper
In addition, aminophylline may have acted synergistically with previously administered epinephrine by inhibiting phosphodiesterase activity or by further releasing endogenous catecholamines [10].
Annals of Internal Medicine  •  1993  |  View Paper
Plasma epinephrine increased from 40 +/- 6 to 57 +/- 9 pg/ml (p less than 0.05), and plasma norepinephrine increased from 406 +/- 63 to 522 +/- 90 pg/ml (p less than 0.01) during the aminophylline infusion.
The American review of respiratory disease  •  1987  |  View Paper
Resistant to two doses of subcutaneous epinephrine (1 mL of 1:1000 dilution) and one intravenous dose of aminophylline (250 mg), the bronchospasm was rapidly relieved by metaproterenol sulfate given by inhalation one hour later.
Archives of internal medicine  •  1984  |  View Paper
Nine subjects had cardiac dysrhythmias related to treatment, principally those receiving epinephrine and aminophylline.
Chest  •  1980  |  View Paper
Aminophylline , an inhibitor of phosphodiesterase, and epinephrine , a beta-adrenergic agent, showed an inhibitory effect, and these effects were reversible.
The Tohoku journal of experimental medicine  •  1979  |  View Paper
These studies demonstrated that intravenous infusion of aminophylline increases the urinary excretion of epinephrine and norepinephrine in man, the rate of excretion of epinephrine being greater than that of norepinephrine.
Circulation  •  1967  |  View Paper
Co-infusion of aminophylline with adrenaline significantly accelerated the rate of mortality.
Cardiovascular research  •  1993  |  View Paper
The presence of the cyclic-AMP phosphodiesterase inhibitor, aminophyline , together with epinephrine slightly increased the enzyme inhibition.
Endocrinologie  •  1990  |  View Paper
Aminophylline when administered three times daily enhanced the protective effect of an acute dose of adrenaline.
International journal of immunopharmacology  •  1982  |  View Paper
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