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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aminophylline
supplement:
Epinephrine
Research Papers that Mention the Interaction
“Infusion of aminophylline had only a minor inhibitory effect on the action of epinephrine.”
Antagonism between glucose and epinephrine regarding insulin secretion. A dose-response study in man.“In addition, aminophylline may have acted synergistically with previously administered epinephrine by inhibiting phosphodiesterase activity or by further releasing endogenous catecholamines [10].”
“Plasma epinephrine increased from 40 +/- 6 to 57 +/- 9 pg/ml (p less than 0.05), and plasma norepinephrine increased from 406 +/- 63 to 522 +/- 90 pg/ml (p less than 0.01) during the aminophylline infusion.”
“Resistant to two doses of subcutaneous epinephrine (1 mL of 1:1000 dilution) and one intravenous dose of aminophylline (250 mg), the bronchospasm was rapidly relieved by metaproterenol sulfate given by inhalation one hour later.”
“Nine subjects had cardiac dysrhythmias related to treatment, principally those receiving epinephrine and aminophylline.”
“ Aminophylline , an inhibitor of phosphodiesterase, and epinephrine , a beta-adrenergic agent, showed an inhibitory effect, and these effects were reversible.”
“These studies demonstrated that intravenous infusion of aminophylline increases the urinary excretion of epinephrine and norepinephrine in man, the rate of excretion of epinephrine being greater than that of norepinephrine.”
“Co-infusion of aminophylline with adrenaline significantly accelerated the rate of mortality.”
Role of nucleoside transport inhibition and endogenous adenosine in prevention of catecholamine induced death in rabbits.“The presence of the cyclic-AMP phosphodiesterase inhibitor, aminophyline , together with epinephrine slightly increased the enzyme inhibition.”
“ Aminophylline when administered three times daily enhanced the protective effect of an acute dose of adrenaline.”
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