Possible Interaction: Aminophylline and Calcium Supplement

“Propofol decreased the concentration of intracellular calcium, whereas aminophylline caused increased mobilization of intracellular calcium in a concentration-dependent manner.”

“However, aminophylline per se is a vasodilator and also changes intracellular levels of cyclic nucleotides and calcium.”

“The effect of increasing calcium concentration in the presence of digoxin and digoxin plus aminophylline in the incubation medium, showed a nonsaturable linear relationship between calcium concentration and intracellular calcium accumulation.”

“The inclusion of digoxin (2 ng/ml) and aminophylline (18.75 micrograms/ml) in the incubation medium showed a significant increase (P less than 0.001) in calcium uptake suggesting a synergistic effect on intracellular calcium accumulation.”

“The results are taken to indicate a complex relation between calcium and substances which stimulate metabolism either of cGMP (sodium ***azide) or cAMP ( aminophylline ) in producing relaxation of the isolated rat uterus.”

“ Calcium uptake by rat diaphragm is a saturable and carrier mediated process that is significantly enhanced in the presence of aminophylline in a dose-dependent pattern that produced maximal effect at 18.75 micrograms/ml.”

“ACTH, isoproterenol, DBcAMP and aminophylline significantly increased ATP-dependent calcium uptake in adipocyte endoplasmic reticulum, but only after they were incubated with intact cells and not when they were added after homogenization.”

“ Aminophylline (1.25 HIM), D- (0.10 mil), and DL-PROP (0.10 DIM) significantly increase the uptake of Ca and P1 from the medium, whereas the addition of ...”

“These results are interpreted to mean that Ca 2 + may be involved in mediating the effects of cyclic AMP and high concentrations of aminophylline , as others have suggested, and that cyclic AMP may be involved in the genesis of the receptor potential.”

“Removal of calcium from the incubation medium diminished release of TSH and GH in response to SME and aminophylline , but had no effect on pituitary cyclic- AMP concentration.”