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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Aminophylline
supplement:
Caffeine
Research Papers that Mention the Interaction
“Expert opinion: Experimental data indicate that caffeine and aminophylline both significantly reduce the anticonvulsant activity of a number of AEDs.”
Safety considerations for patients with epilepsy taking antiepileptic drugs alongside caffeine or other methylxanthine derivatives“Abstention from intake of dietary methylxanthines for 7 days resulted in more rapid and extensive metabolism of aminophylline compared with results from the same subjects on their usual diets.”
“On the other hand, an acute aminophylline injection prolonged the elimination half-life and increased the apparent volume of distribution of caffeine , causing little overall change in its plasma clearance.”
Effect of caffeine on circulating theophylline levels in beagle dogs.“ Aminophylline and caffeine produced an aug mentation of the twitch response of the isolated phrenic nerve diaphragm preparation caused either by direct or indirect stimulation.”
“Three lines of evidence indicate that the intracellular accumulation of cyclic-AMP suppresses SRS-A release: β-adrenergic stimulation with isoproterenol or epinephrine is inhibitory; methylxanthine derivatives inhibit in a dose-response fashion; and synergism is observed when isoproterenol and aminophylline are used together.”
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