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“But though pre-treatment with antioxidants showed differential attenuating effects on aminophylline induced free radical generation as we all known but they were very much ineffective in antagonizing aminophylline induced seizures and post-seizure mortality by any appreciable extent.”
Kathmandu University medical journal • 2014 | View Paper
“Pretreatments with antioxidants , ascorbic acid, alpha-tocopherol and melatonin, all dose dependently reduced seizure incidence and mortality after aminophylline , whereas, antioxidant depletion potentiated such excitotoxicity.”