Possible Interaction: Aminophylline and Antioxidants

“But though pre-treatment with antioxidants showed differential attenuating effects on aminophylline induced free radical generation as we all known but they were very much ineffective in antagonizing aminophylline induced seizures and post-seizure mortality by any appreciable extent.”

“Pretreatments with antioxidants , ascorbic acid, alpha-tocopherol and melatonin, all dose dependently reduced seizure incidence and mortality after aminophylline , whereas, antioxidant depletion potentiated such excitotoxicity.”