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Last Updated: 2 years ago

Possible Interaction: Aminolevulinic Acid and Melatonin

Research Papers that Mention the Interaction

There is an inverse relationship between melatonin and ALA concentrations in both experimental and clinical conditions of porphyria.
Cancer investigation  •  2002  |  View Paper
In the porphyrin biosynthetic pathway, ALA and melatonin acted synergistically by downregulating ALA synthase (ALA-S) and stimulating product formation from ALA; the combination of ALA and melatonin suppressed ALA-S activity, down to about 1% of that in controls.
When given together with ALA, melatonin antagonized these effects and largely protected the integrity of glandular structures.
Free radical biology & medicine  •  2002  |  View Paper
The … delta-aminolevulinic acid … melatonin led to approximately normal levels of delta-aminolevulinate dehydratase, glutathione reductase, catalase and protein carbonyl, and to rises in superoxide dismutase and … deaminase activities; lipid peroxidation remained even lower than in controls and the appearance of the tissue revealed a protective influence of melatonin.
The international journal of biochemistry & cell biology  •  2002  |  View Paper
Melatonin completely counteracted the effects of delta-aminolevulinic acid.
Biochimica et biophysica acta  •  2000  |  View Paper
Co‐treatment with melatonin completely counteracted the effects of ALA.
International journal of cancer  •  2000  |  View Paper
Co-treatment with melatonin completely counteracted the effects of ALA.
Cancer letters  •  2000  |  View Paper
In vivo protection by melatonin against δ‐aminolevulinic acid‐induced oxidative damage and its antioxidant effect on the activity of haem enzymes.
Journal of pineal research  •  1998  |  View Paper
ALA uptake and porphyrin accumulation were increased 30% in incubations with 1.0–2.0 mM ALA for 4 hr in the presence of 2.0 mM melatonin , providing evidence for the involvement of ALA‐promoted ROS in the damage of enzymes related to porphyrin biosynthesis.
In this work we investigated the role of pharmacological concentrations of melatonin on the deleterious effect of ALA and its effect on porphyrin biosynthesis.
These results are further support for the protective role of melatonin against oxidative damage induced by ALA ; this protective action of melatonin is probably due to melatonin's antioxidant and free radical scavenger properties.
Journal of pineal research  •  1997  |  View Paper
Ala , succinylacetone, and gamma-aminobutyric acid significantly decreased plasma melatonin levels independently of blood TRP concentration.
The Journal of clinical investigation  •  1996  |  View Paper
The combination 10(-3) M ALA with 10(-6) M melatonin inhibited retinal porphyrin synthesis after green light adaptation, while in the pigment epithelium green light adaptation induced porphyrin synthesis.
Biochimica et biophysica acta  •  1992  |  View Paper
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