Possible Interaction: Aminolevulinic Acid and Melatonin

“There is an inverse relationship between melatonin and ALA concentrations in both experimental and clinical conditions of porphyria.”

“In the porphyrin biosynthetic pathway, ALA and melatonin acted synergistically by downregulating ALA synthase (ALA-S) and stimulating product formation from ALA; the combination of ALA and melatonin suppressed ALA-S activity, down to about 1% of that in controls.”

“When given together with ALA, melatonin antagonized these effects and largely protected the integrity of glandular structures.”

“The … delta-aminolevulinic acid … melatonin led to approximately normal levels of delta-aminolevulinate dehydratase, glutathione reductase, catalase and protein carbonyl, and to rises in superoxide dismutase and … deaminase activities; lipid peroxidation remained even lower than in controls and the appearance of the tissue revealed a protective influence of melatonin.”

“ Melatonin completely counteracted the effects of delta-aminolevulinic acid.”

“Co‐treatment with melatonin completely counteracted the effects of ALA.”

“Co-treatment with melatonin completely counteracted the effects of ALA.”

“In vivo protection by melatonin against δ‐aminolevulinic acid‐induced oxidative damage and its antioxidant effect on the activity of haem enzymes.”

“ALA uptake and porphyrin accumulation were increased 30% in incubations with 1.0–2.0 mM ALA for 4 hr in the presence of 2.0 mM melatonin , providing evidence for the involvement of ALA‐promoted ROS in the damage of enzymes related to porphyrin biosynthesis.”

“In this work we investigated the role of pharmacological concentrations of melatonin on the deleterious effect of ALA and its effect on porphyrin biosynthesis.”

“These results are further support for the protective role of melatonin against oxidative damage induced by ALA ; this protective action of melatonin is probably due to melatonin's antioxidant and free radical scavenger properties.”

“ Ala , succinylacetone, and gamma-aminobutyric acid significantly decreased plasma melatonin levels independently of blood TRP concentration.”

“The combination 10(-3) M ALA with 10(-6) M melatonin inhibited retinal porphyrin synthesis after green light adaptation, while in the pigment epithelium green light adaptation induced porphyrin synthesis.”