Possible Interaction: Aminolevulinic Acid and Iron, Dietary

“Study C aimed to investigate HO‐1 changes during a three‐day, repetitive administration of ALA and iron.”

“Antioxidant status was impaired after the Fe period, as indicated by decreased FRAP (P < 0.005) and delta-ALAD activity (P < 0.05) and increased EOF (P < 0.01).”

“The participant numbers with impaired glucose tolerance and impaired fasting glucose decreased in the highest dosage group of ALA-P plus iron compared with the placebo group.”

“… -P pl … n de creased the fasting plasma glucose level (2.32 mg/dL, 95% confidence interval [CI], 0.24-4.42, P = 0.029), serum glycoalbumin (0.22%, … 2h-oral glucose tolerance test levels (14.2 mg/dL, 95% CI, 1.8-26.6; P = 0.025) more than the placebo.”

“These results suggest that Hb synthesis is controlled by TfR expression, and that the ALA synthesis is suppressed by iron released from heme and/or Hb due to lowered expression of TfR.”

“The present study evaluated the protective effect of combining 5-aminolaevulinic acid with iron (5-ALA/SFC), a precursor of heme synthesis, to enhance HO-1 activity against CsA-induced chronic nephrotoxicity.”

“It was concluded that in addition to haem, iron may play a regulatory role in controlling the activity of 5-aminolevulinic acid synthetase.”

“After the addition of an optimized concentration (7.5 mg/L) of iron, ALA production by the recombinant Escherichia coli LADF-6 strain that overexpressed hemA, hemL, hemD, and hemF increased to 2840 mg/L in flask cultures.”

“Meanwhile, we found that addition of iron in the medium increased heme formation and reduced ALA yield, whereas the presence of iron chelator in the medium decreased heme concentration and increased the ALA production efficiency (ALA yield per OD600).”

“ Iron and cobalt inhibited the porphyrin synthesis in presence and absence of δ-amino-laevulinic acid (ALA).”