Possible Interaction: Aminolevulinic Acid and Glycine

“In the patients with AIP and in one relative with latent porphyria, glycine loading evoked a significant increase in the urinary excretion of ALA and PBG.”

“The simultaneous application of 5-aminolevulinic acid (3%, 4 h) and glycine (20 microM or 200 microM; n = 10) reduced fluorescence in tumor and surrounding host tissue significantly.”

“Since glycine is decarboxylated in the course of δ-aminolevulinic acid synthesis , the rate of liberation of 14CO2 from [I-14C]glycine can be utilized as a sensitive measure of this reaction.”

“An enhancement of extracellular ALA production under aerobic-dark conditions revealed that the ALA yield was markedly increased 8-fold (48.36 μM) by the addition of 10mM succinate, 4.5mM glycine , and 15 mM levulinic acid (LA).”

“Non-sterial wasterwater slightly reduced the growth and CODcr removal rate of strain 99-28, however the ALA production could be strongly reduced with the addition of LA, glycin and succinate.”

“Moreover, when a second glycine addition was made during the culture, the ALA concentration increased by about 1.5 times compared to that obtained with one glycine addition.”

“On the other hand, the addition of glycine , which is a precursor of ALA biosynthesis via the Shemin pathway in animal cells and some bacteria, enhanced both the specific growth rate and ALA production.”