Possible Interaction: Aminolevulinic Acid and Glutathione

“Significantly, CAT activity, MDA, and GSH levels were in turn, found to be correlated with delta-ALAD (r=-0.45, p=0.00024; r=-0.43, p=0.00053; r=0.43, p=0.00053, respectively).”

“However, substantial cell death was observed in ALA treated cells irradiated in the presence of 15 mM GSH.”

“Application of ALA at 25mg/l dosage significantly enhanced the antioxidant activities e.g. APX, SOD, POD, and GSH contents under Cd stress.”

“Results: Following chronic arsenic (III) exposure, δ-aminolevulinic acid dehydratase activity in blood showed a significant reduction as did the total cell counts (RBC and WBC) and reduced glutathione with increased urinary δ-aminolevulinic acid.”

“The conversion of dioxovaleric acid to aminolevulinic acid was inhibited by the addition of glutathione when a dialyzed bovine liver homogenate served as the source of both glyoxalase I and dioxovalerate transaminase.”

“ ALA pre-… glutathione ( GSH ), ascorbic acid (AsA), total glutathione, and total ascorbate concentrations, and the activities of superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX) and glutathione … decreased the contents of malondialdehyde (MDA) and hydrogen peroxide (H2O2), and superoxide radical (O2 •−) release in both germinating seeds under cold stress.”

“In contrast to ascorbate, the foliar glutathione levels were considerably increased by subtoxic or slightly toxic concentrations of eosin, rose bengal, acifluorfen and ALA in a light-dependent manner.”