Possible Interaction: Aminolevulinic Acid and Gamma-Aminobutyric Acid

“ GABA , β-alanine, and (S)-SNAP-5114 reduced ALA uptake and, to a lesser extent, MAL uptake in the cell lines.”

“Other substances such as β-alanine, GABA, 5-aminovaleric acid, taurine and δ-aminolevulinic acid reduced the basolateral GABA uptake to 6-25% of the uptake in the absence of inhibitor.”

“While the action of glutamate was antagonized by glutamate-receptor blocker--glutamic acid diethyl ester (GDEE), the effects of DALA and baclofen were suppressed upon adding to superfusion medium of GABA uptake inhibitors (nipecotic acid and 2,4-diaminobutyric acid) but not GDEE.”

“These data support the conclusion that delta-aminolevulinic acid can act as an anticonvulsant agent, and mimic the effects of GABA.”

“It was found that … vitro addition of γ‐aminolevulinic acid , as well as GABA agonists such as muscimol and imidazoleacetic …, exhibited a significant suppression of the striatal release of [3H]GABA evoked by the addition of high potassium, whereas γ‐… acid had no significant effects on the evoked release.”

“High affinity GABA uptake by synaptosomes is inhibited by delta-ALA in a competitive fashion at high concentrations (greater than 0.5 mM).”

“Associated with increased ALA is a significant inhibition of neurotransmission utilizing the amino acid γ-aminobutyric acid (GABA), expressed chemically and behaviorally.”

“In addition, it was found that ALA inhibited the stimulated release of GABA from nerve endings probably by acting as an agonist at GABA autoreceptors.”

“It was found that ALA inhibited GABA and glutamate uptake and stimulated basal efflux of the amino acids in purified nerve endings.”

“Here we report that δ-ALA inhibits potassium-stimulated release of GABA from preloaded synaptosomes, probably by acting as an agonist at these presynaptic receptors.”

“The results suggest that some symptoms of acute porphyria might be attributable to a mimicking by ALA of GABA at its central nervous system receptor sites.”

“We report that ALA selectively competes for the binding of tritiated γ‐aminobutyric acid ([3H]GABA) associated with synaptic GABA receptors in central nervous system membranes.”