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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Aminolevulinic Acid and Folic Acid

Research Papers that Mention the Interaction

Folic acid may have a role as an adjuvant in photodynamic therapy with systemically administered ALA and its derivatives.
It was found that the porphyrin production after i.p injection of 200 mg kg(-1) ALA or MAL was significantly increased by i.p injection of 100 mg kg(-1) folic acid.
Two mechanisms may explain the results: enhancement of the efficiency of the rate-limiting enzyme porphobilinogen deaminase by folic acid or interference of folic acid with the transport of ALA and MAL to and into the cells synthesizing porphyrins in the tissues.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology  •  2006  |  View Paper