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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aminolevulinic Acid
supplement:
Folic Acid
Research Papers that Mention the Interaction
“ Folic acid may have a role as an adjuvant in photodynamic therapy with systemically administered ALA and its derivatives.”
“It was found that the porphyrin production after i.p injection of 200 mg kg(-1) ALA or MAL was significantly increased by i.p injection of 100 mg kg(-1) folic acid.”
“Two mechanisms may explain the results: enhancement of the efficiency of the rate-limiting enzyme porphobilinogen deaminase by folic acid or interference of folic acid with the transport of ALA and MAL to and into the cells synthesizing porphyrins in the tissues.”
The effect of folic acid on porphyrin synthesis in tumors and normal skin of mice treated with 5-aminolevulinic acid or methyl 5-aminolevulinate.
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