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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aminoglutethimide
supplement:
Progestins
Research Papers that Mention the Interaction
“AG did not change the blood clearance rate of MPA when the latter was given i. v. This discrepancy between AG's influence on oral and parenteral progestin disposition could be explained by pharmacokinetic properties of the progestins, and our results suggest that AG stimulates the metabolism of progestins.”
“This suggests that AG reduces the biological activity of progestins.”
Influence of aminoglutethimide on the metabolism of medroxyprogesterone acetate and megestrol acetate in postmenopausal patients with advanced breast cancer“At the same time, the FSH-stimulated progestin production during the induction period was inhibited in a dose-related fashion by AG.”
Aminoglutethimide augments follicle-stimulating hormone-induced aromatase activity in cultured porcine granulosa cells.
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