Possible Interaction: Aminoglutethimide and Glutathione

“Sequentially, GSH induced aggregation of Ag NPs which resulted in a decrease in absorption intensity of Ag NPs plasmonic band and a color change from red to gray.”

“ Ag ions reacted with the -SH group of antioxidant molecules, such as glutathione , and induced intracellular oxidative conditions.”

“However, a statistically significant (ANOVA/Tukey) increase in GSH per cell was observed upon exposure to Ag (50%), Co (100%), Hg (250%) and Zn (10%).”

“The reducing reagents Tris-2-carboxyethly-phosphine, dithiothreitol (DTT), and glutathione , as well as the oxidizing agent H(2)O(2) used at experimentally relevant concentrations reacted with Ag in the electrodes to produce voltage offsets.”

“Meanwhile, CAT and GSH activities were significantly diminished and the AG supplementation significantly (p < 0.001) ameliorated these effects compared with the control and AG-treated groups.”

“Well-dispersed Ag NPs in suspension can form aggregates upon reacting with glutathione (GSH) via Ag-SH covalent bonds and electrostatic attraction, with the color changing from bright yellow to red.”

“The Raman spectral intensities of the MCB-assembled Ag and Au NPs decreased after treatment with either potato dextrose agar (PDA) or glutathione (GSH).”

“The Ag nanomaterials also reduced the quenching of DPPH by GSH to varying degrees.”

“… Ag was found to increase in a concentration dependent manner with a maximum of 29.3 microg g(-1) at 20 microM. … pigments, chlorophyll a fluorescence parameters (Fo, Fv, Fv/Fm, Fv/Fo), malondialdehyde (MDA), ATP, peroxidase (POD) activity, ascorbate (AsA), reduced glutathione ( GSH ) and protein contents … Ag augmented.”