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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Aminoglutethimide
supplement:
Epinephrine
Research Papers that Mention the Interaction
“ AG is now considered to act as an inhibitor of the aromatization of mainly adrenal androgens to estrogens in peripheral tissues and/or breast cancer itself.”
Second line endocrine treatment of postmenopausal advanced breast cancer. Preliminary endocrine results of a 5-ARM randomized phase II trial of medium vs low dose aminoglutethimide, with or without hydrocortisone vs hydrocortisone alone (EORTC 10861)“ Aminoglutethimide is an inhibitor of adrenal steroid biosynthesis and blocks the conversion of cholesterol to pregnenolone, and therefore reduces levels of adrenal androgens , which are a source of estrogens in both premenopausal and postmenopausal women.”
“Glucocorticoids, synthetic steroidal antiandrogens, aminoglutethimide , ketoconazole, and spironolactone also may be used to block adrenal androgens.”
“Treatment of murine epidermal cell preparations with epinephrine (EPI) or norepinephrine inhibited Ag presentation in vitro.”
Catecholamines Inhibit the Antigen-Presenting Capability of Epidermal Langerhans Cells1
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