Possible Interaction: Aminoglutethimide and Copper

“It was shown that combination of Cu and Ag NPs, as well as GO-Cu-Ag nanocomposite material possess enhanced antibacterial activity through a possible synergy between multiple toxicity mechanisms.”

“The association of Cu-Ag causes a higher pregnancy rate than when the vector carries Cu alone, as Ag apparently depotentiates the contraceptive action of Cu.”

“Due to the 3D porous … strong plasmonic coupling between Ag … Cu , the porous AgNPs/Cu substrate achieves ultrasensitive detection of multiple analytes as low as 10-11 M (crystal violet, … M (malachite green, MG), 10-11 M (acephate), and 10-9 M (thiram) even with a portable Raman device.”

“A strong synergistic bactericidal behavior between Ag and Cu ions was detected, which allowed to decrease the concentration of Ag ions by 10-fold, while maintaining the same level of antibacterial activity.”

“Metals with similar modes of action did competitively interact in some instances, but not others, and when they did compete the competition was not necessarily reciprocal (e.g., Cu inhibited Ag uptake but Ag did not inhibit Cu uptake).”

“The metals silver Ag ) and copper (Cu), known to be antagonistic to Na uptake in other aquatic taxa did not generally exhibit this effect in aquatic insects.”

“Toxic unit calculation suggests additive effects of Cu and Ag in mixture at 18 and 20 °C.”

“Concentrations of Cu and Ag were significantly positively correlated with one another, as were concentrations of Se and Zn.”

“Similarly, the inhibitory effect of Cu and Ag in mixture on branchial Na(+) uptake was significantly greater than that of Cu or Ag alone.”

“The presence of elevated luminal Ag stimulated Cu and Na+ uptake.”