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Discover Supplement-Drug Interactions

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Possible Interaction: Amiloride and Yohimbine



Research Papers that Mention the Interaction

The effect of competition between two amilorides on yohimbine dissociation also was explored.
Molecular pharmacology  •  1998  |  View Paper
Allosteric modulation of [3H] yohimbine binding by Na+, H+, and 5-amino-substituted analogs of amiloride also was demonstrated for the alpha 2-receptor expressed in COS-M6 cells.
The Journal of biological chemistry  •  1990  |  View Paper
Amiloride inhibited [3H]yohimbine and [3H]prazosin binding to alpha 2- and alpha 1-adrenoreceptors, respectively, from various tissues in a concentration-dependent manner.
Amiloride inhibited [3H]yohimbine binding noncompetitively and [3H]prazosin binding competitively.
Amiloride was approximately 9-12 times more potent in inhibiting [3H]yohimbine binding to alpha 2-adrenoreceptors from rat tissues than from other mammalian tissues.
Further, in rat tissues, amiloride was approximately 10 times more potent in inhibiting [3H]yohimbine than [3H]prazosin binding.
Canadian journal of physiology and pharmacology  •  1988  |  View Paper