Possible Interaction: Amiloride and Thiamine

“The diuretic amiloride caused a concentration‐dependent inhibition in thiamine uptake, whereas the anti‐trypanosomal drug, melarsoprol, failed to affect the uptake process.”

“… thiamine structural analogs amprolium and oxythiamine, but not by unrelated … choline; and 6) inhibited in a competitive manner by amiloride with an inhibition constant of 0.2 mM. The role of specific protein kinase-mediated … uptake by Caco-2 cells was also examined using specific modulators of these pathways.”