Possible Interaction: Amiloride and Potassium

“Replacing a potassium supplement with amiloride increased the antihypertensive effect.”

“In both of these disorders, despite the rise in plasma potassium levels, amiloride produced a counter-therapeutic rise in PA which could potentiate further potassium losses.”

“A comparison with the results of an earlier study, in which hydrochlorothiazide was given without amiloride, showed that the intracellular potassium depletion and the increase in intracellular sodium concentration, observed with the benzothiazide diuretic, could be fully prevented by simultaneous administration of amiloride.”

“At submaximal dosages, amiloride potentiated the natriuresis and reduced the potassium loss evoked by ethacrynic acid.”

“ Amiloride can be considered in serious potassium loss.”

“In one prospective, controlled study of hypokalemia with AmB administration, patients receiving concomitant amiloride had significantly greater potassium concentrations (p < 0.01) and required significantly less potassium supplementation (p < 0.001).”

“Plasma potassium rose significantly on amiloride (3.64 +/- 0.24 vs 4.07 +/- 0.54 mmol/l, P < 0.05).”

“The decrement in potassium loss during concomitant amiloride treatment cannot be explained.”

“ Amiloride caused a significant rise in exchangeable potassium , exchangeable potassium/kg body weight, and plasma potassium, together with a significant fall in plasma total carbon dioxide, body weight, systolic and diastolic blood pressures.”

“Patients who were given amiloride needed less potassium supplementation than those in the control group (P< o oo5) and yet maintained significantly higher plasma potassium levels (P< o os).”