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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amiloride
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“ Amiloride acted primarily as a competitive antagonist, reducing the sensitivity of the receptor to GABA without affecting the maximal current amplitude.”
Amiloride inhibition of gamma-aminobutyric acid(A) receptors depends upon the alpha subunit subtype.“On the basis of these results we conclude that amiloride and verapamil inhibit high K+-induced release of [3H]GABA by antagonizing the entrance of Ca2+ (and possibly Na+ when external Ca2+ is absent) through a population of voltage sensitive presynaptic Ca2+ channels activated by depolarization.”
Vesicular and carrier-mediatied depolarization-induced release of [3H]GABA: Inhibition by amiloride and verapamil“Drugs such as acetazolamide or amiloride can block GABA depolarization.”
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