Possible Interaction: Amiloride and Epinephrine

“In the rat lungs, amiloride (a sodium channel blocker) caused a greater decrease in alveolar fluid clearance and epinephrine clearance rate than propranolol (a nonselective β-adrenergic antagonist).”

“This effect of adrenaline was inhibited by amiloride or EIPA, indicating that adrenaline stimulated NHE 1.”

“Initial incubation with AMI and later in RH caused a drop in reaction to EPI and no effect on mechanosensitivity.”

“The addition of adrenaline plus amiloride led to a rapid significant increase in the R TM (p !”

“ Amiloride inhibited the Na and Cl influxes of the control period (by −8.63±1.28 and −2.08±0.75 neq·cm−2·min−1, respectively) but did not prevent the increase of these fluxes on the addition of adrenaline.”

“ Amiloride (10−4 M) inhibited the adrenaline response (Jv amiloride, +5·46 ± 1·09 ml h−1; P< 0·005).”

“… amiloride to lung liquid did not reverse the inhibitory effects of asphyxia on lung liquid …. 0.7 +/- 0.4 ml/h) but did block the inhibitory effects of both epinephrine (14.8 +/- 4.4 vs. 13.8 +/- 3.1 ml/… +/- 3.7 vs. 19.5 +/- 5.0 ml/h).”

“The voltage clamp technique was used to test if the inhibitory effect of adrenaline on amiloride‐resistant , HCO3(‐)‐dependent pHi recovery was due to an efflux of HCO3‐ ions through catecholamine‐activated anion channels.”

“In the fetus addition of amiloride (0.8 x 10(‐4) M) to the luminal fluid blocked adrenaline‐induced liquid absorption and caused secretion to occur at 1.3 (+/‐ 0.3) ml (kg body weight)‐1 h‐1.”

“This exchange stimulated by adrenaline through beta adrenoreceptors and inhibited by amiloride added to the external medium.”