“In prior studies, we have shown that the antikaliuretic drugs, triamterene and amiloride , through a direct cardiac effect reduce the loss of cardiac potassium induced by the administration of digitalis.”
“These studies have demonstrated that through a cardiac effect, by reducing the digitalis-induced loss of cardiac potassium, the potassium-sparing drugs, triameterene and amiloride , extend the toxic dose of digitalis and thus permit txtension of its inotropic activity.”