Possible Interaction: Amiloride and Calcium Supplement

“Furthermore, the sodium proton exchanger blocker amiloride also partially inhibited the calcium rise and the cell death elicited by MTX while the combination of amiloride and ML204 fully prevented both the cytotoxicity and the calcium rise elicited by the toxin.”

“ Amiloride inhibited the long-term rise of intracellular Ca++ induced by raised extracellular Ca++, without blocking the initial increase of intracellular Ca++.”

“ Amiloride , which inhibits Na+/H+ exchange, inhibited only 10% of the Ca2+ -enhanced countertransport.”

“The Ca2+-activated Na+ efflux and influx had an apparent Km for activation by Ca2+o of about 25 microM. The Ca2+ -dependent Na+ transport was inhibited 30-60% by amiloride (ID50 = 17.3 +/- 8 microM).”

“ Ca++ , instead, only blocks a fraction of the SCC, and this fraction seems to correspond to the inhibition of the same population of Na sites blocked by the “late” phase of amiloride effect.”

“Chronic treatment with CBI, DEAI, enduron, and amiloride significantly improved the myofibrillar ATPasc activity at all pCa2+ concentrations (p<0.01).”

“ Amiloride resulted in a concentration-dependent inhibition of peak ( Ca ,L), But amiloride did not change the shape of their I - V curves.”

“ Amiloride (100 μmol·l-1) on the apical side inhibited ca.”

“In rat parotid acini, amiloride inhibited the secretion of amylase and the efflux of calcium and rubidium in response to carbamylcholine and to norepinephrine.”

“Resting membrane voltage, measured with the voltage-sensitive dye DiOC6 (3), averaged -70 mV. Amiloride hyperpolarized cells in a reversible manner by 18 mV. Control rates of Ca uptake averaged 2.8 nmol/(min mg protein) and increased by 39% in the presence of amiloride.”